Safe & Effective Cross-Sex Hormone Therapy

The complexities and hardships of being transgender, transsexual or gender-nonconforming are countless. Every person’s experience is different, but most face pervasive discrimination, even in medical care. A huge issue for many trans and gender-nonconforming men and women is access to adequate healthcare or to a physician who understands how to treat their unique health issues and hormone therapy (HT) needs.

Many Physicians Lack Knowledge & Expertise in Cross-Sex Hormone Therapy

According to the latest medical guidelines, feminizing/masculinizing hormone therapy for many transsexual, transgender, and gender-nonconforming individuals is considered a medical necessity.1 And yet, physicians—both past and present—have had to rely on trial and error or guesswork in dosing to achieve the desired results. There is still no long term research data available to guide the medical community in proper dosing or comparing the effectiveness and safety of different delivery methods or different types of hormones for these patients. Most doctors don’t even know where to start.

A survey published in 2016 reported that “endocrinologists and other providers have received more education and training on transgender care within the past decade. Nevertheless, many participants (in the survey) have had little opportunity to care for transgender patients, and they rate their competency to do so as low.”2

Transsexual, Transgender & Gender-Nonconforming Individuals Need Safe & Effective Hormone Therapy

It’s a medical reality that trans and gender-nonconforming individuals who wish to maintain cross-sex characteristics must use feminizing/masculinizing hormone therapy for the rest of their lives. Many are using high dose, pharmaceutical synthetics despite the abundant scientific evidence showing that these drugs are linked to serious health risks. That’s why the labels recommend taking the least amount for the shortest period of time. This isn’t possible for people needing cross-sex hormone therapy. They require hormones around-the-clock, every day of the year. Because of this, guidelines are very clear on the need for careful risk assessment and monitoring of patients receiving this type of treatment.

It is reassuring, however, that increasing numbers of physicians who provide this therapy and other HRT are shunning risky pharmaceutical synthetics and opting for bioidentical hormones instead. There are many studies showing that human identical hormones, when properly administered, can be more beneficial, safer and more effective than non-identical patented drugs.3,4,5

What Makes SottoPelle® a Perfect Fit for Cross-Sex Hormone Treatment?

SottoPelle® has been treating hormone issues of all kinds far longer than most in our field. We know that cross-sex hormone treatment can be delicate to administer. It requires a precision method and an expert who understands both the desired outcome and how to achieve it. Remarkably, we find that our method is a perfect fit for transsexual, transgender and gender-nonconforming men and women. In fact, Dr. Gino Tutera, the founder and creator of our SottoPelle® method, realized the need for healthier treatment options and began working these patients back in the mid-1990s—20 years ago!

The SottoPelle® Method

SottoPelle’s proprietary method allows us to tailor your hormone therapy according to your unique needs. Our goal is to not only help you successfully transition, but to provide hormonal balance as well—something other methods or even other pellet therapies cannot deliver.

SottoPelle® employs a proprietary bioidentical pellet implant method that sends a steady, low dose of hormone directly into the blood stream. Precisely dosed hormones are delivered around-the-clock, seven days a week for up to six months. The body recognizes and can work with this type of delivery method. In fact, it is the only system that allows more hormone to be delivered when the body needs it.

You will find that our SottoPelle® method is not only more convenient and better attuned to the way your body works naturally, but it is also far more cost-effective than other cross-sex hormone treatments.

SottoPelle® BHRT Pellet Experts

SottoPelle® has specialized in bioidentical hormone replacement using the pellet method longer than most. Our founder, Dr. Gino Tutera, developed the proprietary method that makes us a leader in our field. We have a long history of success when it comes to balancing hormones and helping people take control of their health. In fact, we are honored to say that, according to Ranking Arizona, an annual consumer publication by AZ Big Media, our patients have voted us Arizona’s #1 Hormone Therapy Clinic for two years in a row.

Call Us Today!

Consulting with an expert in SottoPelle’s science-based BHRT can go a long way in providing a healthier transition and future for you. If you are a male or female looking for safe, effective cross-sex hormone treatment, call SottoPelle® today. Discover what our remarkably simple, hassle-free method can do for you.

Learn more about SottoPelle® at and then give us a call at (877) 473-5538 to schedule a consultation.

1Coleman et al. Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7. International Journal of Transgenderism; August 2012, 13(4): 165-232.
2 Michael S. Irwig (2016) TRANSGENDER CARE BY ENDOCRINOLOGISTS IN THE UNITED STATES. Endocrine Practice: July 2016, Vol. 22, No. 7, pp. 832-836.
3 Conaway E. Bioidentical Hormones: An Evidence-Based Review for Primary Care Providers. The Journal of the American Osteopathic Association, March 2011, Vol. 111, 153-164. doi:10.7556/jaoa.2011.111.3.153
4 Schwartz E, Holtorf K. Hormones in wellness and disease prevention: common practices, current state of the evidence, and questions for the future. Prim Care Clin Office Pract 2008; 35 (4): 669–705.
5 Moskowitz D. A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Altern Med Rev. 2006 Sep;11(3):208-23.