Hormones,  The Brain and Mental Health

Studies show the brain contains thousands of hormone receptors for estrogen, testosterone and progesterone that regulate neurotransmitters like dopamine, serotonin, oxytocin, and endorphins. These “feel good” chemical messengers, often called “the happiness hormones,” influence mood, memory, mobility, concentration, sleep, appetite, cognitive function, and mental health.

The neurotransmitters rely on the proper balance of the sex hormones not only for brain and mental health but also for protection against neurodegenerative diseases. Scientific research is now proving what Dr. Gino Tutera discovered over 15 years ago: the direct and intricate link between hormones and the brain. Dr. Tutera used the SottoPelle® Method for patients with Parkinson’s disease, Alzheimer’s, Traumatic Brain Injury, concussions, depression, and dementia with positive results.

The following content highlights how hormones impact the brain and mental health and the science-based studies supporting Dr. Tutera’s groundbreaking work using SottoPelle® in this field.

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How Hormones Impact the
Brain & Mental Health

Heal Traumatic Brain Injury with Bioidentical Hormones

“Heal Traumatic Brain Injury with Bioidentical Hormones”

Compiled by Michael Downey

As seen in Life Extension, Feb. 2015

Traumatic brain injury afflicts nearly 1.7 million Americans annually and causes devastating cognitive, emotional, and physical deficits.

Standard therapies frequently fail to provide significant recovery after the acute phase, and chronic symptoms can linger over a lifetime. Many patients are unable to fully re-enter society.

Innovative physicians are discovering that brain trauma can trigger deficiencies in certain hormones. When these hormones are restored using precise bioidentical therapy, a reversal of functional deficits associated with traumatic brain injury has been shown.

Beyond brain injuries, accumulating evidence suggests that—as rates of dementia and Alzheimer’s disease continue to explode—replenishing these same hormones may also help inhibit these degenerative brain diseases.

… And just as Dr. Tutera has shown that TBI symptoms can be treated and possibly reversed with sex hormones, the same hormones have been shown to reduce the risk of neurodegenerative diseases such as Alzheimer’s disease.

Hormones and Happiness: An Insight into Our Brain Chemistry

“Hormones and Happiness: An Insight into Our Brain Chemistry”

by Catherine J. Rourke

As seen in USA Today, Aug. 24, 2023

Neurobiology may sound complex, but boosting your brainpower is simple with SottoPelle® science.

“While this represents time-revered endocrinology and isn’t rocket science,” said Tutera, “BHRT offers a solution backed by studies in the prevention of serious maladies to offset the development of major diseases.”

According to Dr. Tutera, “This is the only safe, effective approach to eliminating the root of all disease and physical dysfunction by restoring hormonal balance, normal neurotransmitter processes and normal physiology of the body. It’s the best preventative antidote in modern medicine to alleviate the devastating illnesses and often fatal diseases caused by stress.”
As pioneers bringing pellet therapy back into the mainstream with precision dosing, SottoPelle® paved the way decades ago as the visionary industry leader for pellet practices across America.

Today, Dr. Tutera’s wife CarolAnn continues his legacy as president of SottoPelle®, now celebrating 30 years helping more than 250,000 patients worldwide enjoy happier, healthier lives.

Harmonize Your Hormones for Health and Happiness

“Harmonize Your Hormones for Health and Happiness”

by Karen Sheedy
Written in partnership with Catherine J. Rourke


As seen on Woman’s World , Nov. 13, 2023

Feeling frazzled, fatigued, funky and foggy-headed? Do you keep misplacing those car keys or spacing out names and numbers? Maybe you’re constantly down in the dumps.

As women age and experience menopause, they undergo dramatic changes in their bodies and brains, from memory loss, mood swings and insomnia to fluctuations in appetite, weight and stress.

The World Health Organization estimates that many of the 50 million women in the U.S. over age 51 face cognitive decline and related mental conditions such as Alzheimer’s, dementia and depression.

According to a 2023 Columbia University Irving Medical Center report, the spike in cognitive disorders for women over age 45 remains a growing health concern, with women representing 65 percent of Alzheimer’s patients.

The good news: there are steps you can take to cut your risk and stay happy and healthy at any age. And it starts with your hormones.

“Improve your brain health by balancing hormones”

An Interview with
Steve Nunn, MPAS, PA-C, DFAAPA

Oct. 30, 2023

Sonoran Living. ABC 15 Arizona

Neurobiology may sound complex, but boosting your brain health is simple with SottoPelle®. Scientific research shows that hormones set the stage in motion for every function of the body and brain. Hormones trigger the release of chemical messengers that signal every cell to do its physical and mental job.

BHRT pellets release a consistent supply of plant-based hormones to the brain receptors, so every synapse, neurotransmitter and mitochondria receives the correct amount exactly when it is needed on a 24-7 basis for balanced physiology. Neuroscientists and medical researchers are now confirming what Dr. Tutera discovered over a decade ago: the intricate connection between hormones and brain health. Studies show that BHRT pellets not only enhance mood and cognitive function but also regulate the brain’s neurotransmitters.


Internationally recognized as the foremost leader in bio-identical hormone replacement pellet therapy, Dr. Gino Tutera, MD, FACOG, developed the SottoPelle® Method in 1992 to improve human health and help patients age gracefully.

Photo credit: King Lawrence Photographer/kinglawrence.com


Not all hormones are alike. Natural, plant-based BHRT pellets slipped easily under the skin serve as a 24-7 delivery system with precision dosing to restore the body’s normal physiology without synthetic hormone chemicals.

Photo credit: King Lawrence Photographer/kinglawrence.com


As visionary industry leaders for custom-dosed BHRT pellet therapy since 1992, Dr. Tutera and his wife CarolAnn paved the way for global pellet practices with the SottoPelle® Method, now celebrating 30 years of helping 250,000 patients worldwide.

Photo credit: King Lawrence Photographer/kinglawrence.com


The sex hormones transmit neural signals to the brain’s hormone receptors, triggering the release of the feel-good neurotransmitters dopamine, serotonin, oxytocin and endorphins that influence mood and emotions.

Graphic: Andrade Design, California/Andradedesign.com

Why the SottoPelle® Hormone Method?

Jim McMahon & CarolAnn Tutera on Les Norman Radio Show

Jim McMahon & CarolAnn Tutera on Les Norman Radio Show

Two-time Super Bowl, Super Star and Pro Bowl QB, Jim McMahon has a long and storied health history. After playing football as a child to 15 years in the pros, he suffered many injuries to his body and his brain. He has been very forthcoming about his memory problems from CTE and his brushes with depression and low motivation. He needed help and didn’t know where to turn. It was 10 years ago that McMahon first discovered Sottopelle bio identical hormone replacement pellets.

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2023 in Review: Advancements in Hormone Replacement Therapy

2023 in Review: Advancements in Hormone Replacement Therapy

2023 marked a year of significant progress in the field of HRT. Research advancements, clinical trials, and increased awareness are paving the way for more personalized, effective, and accessible treatment options for physicians administering hormone replacement therapy to improve their patients’ health and quality of life.

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Physician Hormone Training: Can TBIs be Treated With Progesterone?

Physician Hormone Training: Can TBIs be Treated With Progesterone?

While progesterone has long been considered exclusively a female reproductive hormone, numerous studies now show that it has wide ranging neuroprotective properties in humans. In this article, we share some revelatory research on progesterone replacement therapy to improve neurological outcome after traumatic brain injury.

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Is Male Testosterone Deficiency Linked to Cardiovascular Disease?

Is Male Testosterone Deficiency Linked to Cardiovascular Disease?

After age 40, men’s testosterone levels will begin to decrease. This decrease is linked to an increase in mortality and cardiovascular risks, as well as a greater risk of developing type 2 diabetes, coronary artery disease (CAD), and metabolic syndrome. Testosterone replacement can improve many of the cardiovascular diseases of older men.

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Grow Your Practice with Physician Hormone Therapy Training

Grow Your Practice with Physician Hormone Therapy Training

Over 116 million Americans, roughly 35% of the population, are aged 50 and over. And this will swell to 160 million by 2040, nearly 40% of the population. Preparing for this demographic revolution is a necessity for physicians who wish to better serve their patients’ needs in addition to growing their practice.

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Physician Hormone Therapy Training for Hypothyroidism

Physician Hormone Therapy Training for Hypothyroidism

While 1 in 300 persons in the U.S. suffers from hypothyroidism, it is often misdiagnosed. This is especially true menopausal women. Accurate physician identification of hypothyroidism is extremely important for developing an individualized treatment plan for patients.

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