trans hormone therapy

7 Myths About Feminizing Estrogen Therapy

hormone replacement therapy

Types of Transgender Feminizing Hormone Therapy

Safe & Effective Cross-Sex Hormone Therapy

The complexities and hardships of being transgender, transsexual or gender-nonconforming are countless. Every person’s experience is different, but most face pervasive discrimination, even in medical care. A huge issue for many trans and gender-nonconforming men and women is access to adequate healthcare or to a physician who understands how to treat their unique health issues and hormone therapy (HT) needs.

Many Physicians Lack Knowledge & Expertise in Cross-Sex Hormone Therapy

According to the latest medical guidelines, feminizing/masculinizing hormone therapy for many transsexual, transgender, and gender-nonconforming individuals is considered a medical necessity.1 And yet, physicians—both past and present—have had to rely on trial and error or guesswork in dosing to achieve the desired results. There is still no long term research data available to guide the medical community in proper dosing or comparing the effectiveness and safety of different delivery methods or different types of hormones for these patients. Most doctors don’t even know where to start.

A survey published in 2016 reported that “endocrinologists and other providers have received more education and training on transgender care within the past decade. Nevertheless, many participants (in the survey) have had little opportunity to care for transgender patients, and they rate their competency to do so as low.”2

Transsexual, Transgender & Gender-Nonconforming Individuals Need Safe & Effective Hormone Therapy

It’s a medical reality that trans and gender-nonconforming individuals who wish to maintain cross-sex characteristics must use feminizing/masculinizing hormone therapy for the rest of their lives. Many are using high dose, pharmaceutical synthetics despite the abundant scientific evidence showing that these drugs are linked to serious health risks. That’s why the labels recommend taking the least amount for the shortest period of time. This isn’t possible for people needing cross-sex hormone therapy. They require hormones around-the-clock, every day of the year. Because of this, guidelines are very clear on the need for careful risk assessment and monitoring of patients receiving this type of treatment.

It is reassuring, however, that increasing numbers of physicians who provide this therapy and other HRT are shunning risky pharmaceutical synthetics and opting for bioidentical hormones instead. There are many studies showing that human identical hormones, when properly administered, can be more beneficial, safer and more effective than non-identical patented drugs.3,4,5

What Makes SottoPelle® a Perfect Fit for Cross-Sex Hormone Treatment?

SottoPelle® has been treating hormone issues of all kinds far longer than most in our field. We know that cross-sex hormone treatment can be delicate to administer. It requires a precision method and an expert who understands both the desired outcome and how to achieve it. Remarkably, we find that our method is a perfect fit for transsexual, transgender and gender-nonconforming men and women. In fact, Dr. Gino Tutera, the founder and creator of our SottoPelle® method, realized the need for healthier treatment options and began working these patients back in the mid-1990s—20 years ago!

The SottoPelle® Method

SottoPelle’s proprietary method allows us to tailor your hormone therapy according to your unique needs. Our goal is to not only help you successfully transition, but to provide hormonal balance as well—something other methods or even other pellet therapies cannot deliver.

SottoPelle® employs a proprietary bioidentical pellet implant method that sends a steady, low dose of hormone directly into the blood stream. Precisely dosed hormones are delivered around-the-clock, seven days a week for up to six months. The body recognizes and can work with this type of delivery method. In fact, it is the only system that allows more hormone to be delivered when the body needs it.

You will find that our SottoPelle® method is not only more convenient and better attuned to the way your body works naturally, but it is also far more cost-effective than other cross-sex hormone treatments.

SottoPelle® BHRT Pellet Experts

SottoPelle® has specialized in bioidentical hormone replacement using the pellet method longer than most. Our founder, Dr. Gino Tutera, developed the proprietary method that makes us a leader in our field. We have a long history of success when it comes to balancing hormones and helping people take control of their health. In fact, we are honored to say that, according to Ranking Arizona, an annual consumer publication by AZ Big Media, our patients have voted us Arizona’s #1 Hormone Therapy Clinic for two years in a row.

Call Us Today!

Consulting with an expert in SottoPelle’s science-based BHRT can go a long way in providing a healthier transition and future for you. If you are a male or female looking for safe, effective cross-sex hormone treatment, call SottoPelle® today. Discover what our remarkably simple, hassle-free method can do for you.

Learn more about SottoPelle® at and then give us a call at (877) 473-5538 to schedule a consultation.

1Coleman et al. Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7. International Journal of Transgenderism; August 2012, 13(4): 165-232.
2 Michael S. Irwig (2016) TRANSGENDER CARE BY ENDOCRINOLOGISTS IN THE UNITED STATES. Endocrine Practice: July 2016, Vol. 22, No. 7, pp. 832-836.
3 Conaway E. Bioidentical Hormones: An Evidence-Based Review for Primary Care Providers. The Journal of the American Osteopathic Association, March 2011, Vol. 111, 153-164. doi:10.7556/jaoa.2011.111.3.153
4 Schwartz E, Holtorf K. Hormones in wellness and disease prevention: common practices, current state of the evidence, and questions for the future. Prim Care Clin Office Pract 2008; 35 (4): 669–705.
5 Moskowitz D. A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Altern Med Rev. 2006 Sep;11(3):208-23.

What Transgender People Need to Know About Safe & Effective Hormone Treatment

Transitioning from male to female or female to male is a tremendous undertaking. There is a lot of confusion and mythology surrounding hormone therapy, making it critical to do your research before signing on. Above everything, you want to make sure that you have selected the safest and most effective hormone treatment. Since you will be on these hormones for the rest of your life, you need to understand what to look for. Here are some guidelines and tips for you:

  • At all costs, avoid synthetic testosterone, estrogens and progestins. These substances do not match human hormones and fail to provide the benefits of human-made hormones. In fact, there is a large volume of research literature dating back decades that shows the risks and serious side effects of using synthetics.
  • Health-wise, it is vital to use bioidentical hormones. Bioidenticals exactly match the hormones your body makes. They have the same chemical and molecular structure. This enables them to stimulate receptors throughout the body and perform the beneficial work of human hormones.
  • The hormone delivery method makes all the difference! Common delivery modalities are plagued with drawbacks.

Transgender Hormone Treatment

PILLS can be expensive and inconvenient. Hormones in this form must first pass through the GI tract and liver, where they are quickly metabolized. This means larger doses are required in order to be effective. These large dosages create health risks, affecting clotting factors, lipoproteins and inflammatory factors.

PATCHES are messy, expensive and must be changed regularly. Many users experience adhesive allergies, skin irritation and other issues.

GELS and CREAMS are also messy and expensive. They have many drawbacks including frequent application; difficulty in assessing and monitoring doses; and harmful effects on others, including children and pets, when skin-to-skin contact occurs.

INJECTIONS are expensive and rely on unsafe synthetics. They cannot maintain beneficial blood levels, which spike initially and rapidly decline after one or two weeks. Long term use is impossible as resistance to the synthetic hormones builds over time.

Given all of these negatives, you must wonder if any hormone therapy is safe, convenient and effective.

The answer is yes.

Bioidentical Pellet Implant Therapy has been prescribed and researched since the 1930s. When properly administered and monitored, this treatment can be safely used for a lifetime.
Benefits of Bioidentical Pellets:

  • The only treatment that allows your body to control the release of hormone—raising levels when more is needed and decreasing it when it needs less
  • Deliver a very low dosage continuously around the clock
  • Release testosterone and/or estradiol directly into the bloodstream, bypassing the gastrointestinal system and liver
  • Consistently proven more effective than oral, injected, or topical methods with regard to sexual function, mood and cognitive function, metabolic function, bone density, urinary, prostate and vaginal problems, lipid profiles, breast health and hormone ratios
  • Typically last from 3 to 6 months

On a final note, the key, as a transgender individual, is to find an expert who understands bioidentical hormones, pellet therapy, and the desired outcome for transgender patients.

So why is SottoPelle® the BHRT of choice for so many transgender men and women?

Because we’re industry leaders and expert at what we do. Unlike others:

  • SottoPelle® uses the most reliable delivery system available—pellet implants.
  • Our proprietary dosing system is based in science, not guesswork. This enables SottoPelle® physicians to precisely determine the proper low dosage of bioidenticals for you as a transgender individual.
  • We use a time-proven insertion technique to assure a consistent steady delivery of testosterone and/or estradiol, 24/7.
    And we’ve been doing this a lot longer than most. With 23+ years of experience, we understand exactly what it takes to create a healthy state of balance and well-being for you.

Remember, not all pellet therapies are alike. Not every physician has the expertise to balance hormones. And that’s exactly what it takes to sustain a healthy body and support your health as you transition and thereafter.

Which Transgender Hormone Treatment is Safe and Effective?

Being transgender brings with it layers of diversity and complexities not to mention a long list of struggles. These can range from emotional, psychological and social issues, to legal, employment and travel discrimination, and the litany goes on. One of the biggest hurdles transgender patients face is finding a doctor who can treat their hormonal issues safely, effectively and correctly.
Frankly, most doctors lack the knowledge and experience to help transgender patients and many don’t even know where to start. For years there has been a distinct lack of long term studies to aid doctors in treating these individuals. Nonetheless for more than 60 years in the U.S. and 70 years in Western Europe, doctors have experimented with cross-sex hormone treatments based on the recommendations of expert opinions. They’ve had to do this without the reassurance of solid data related specifically to transgender concerns.

SottoPelle® has been treating hormone issues of all kinds far longer than most in our field. Cross-sex hormone treatment can be delicate to administer. It requires both a precision method and an expert who understands the desired outcome. Remarkably, we find that our method is a perfect fit for transgender individuals and have been successfully treating transgender females and males for two decades now.

What Makes SottoPelle® so Perfect for Transgender Hormone Treatment?

Bioidentical Hormones
We use plant-based hormones that exactly match human hormone. Studies have shown for decades that bioidentical hormone therapy, when properly administered, is both safe and effective. Side-effect laden synthetic hormones are simply not the healthiest choice. Research consistently associates them with serious health risks.

Pellet Implant Method
The pellet implant method been successfully used since the 1930s. Research studies support it as the most effective and safe method of hormone delivery available. This method sends a steady, low dose of hormone directly into the blood stream. Hormones are delivered around the clock, seven days a week for up to six months. The body recognizes and can work with this type of delivery method. In fact, it is the only system that allows more hormone to be delivered when the body needs it.

More Convenient & Safer Than Other Methods
You will not need a daily pill box full of harmful drugs to help create your transgender transformation. Our approach is safer, more natural, much simpler and straightforward. We monitor any health risks closely and work in tandem with other participating physicians.

It’s important to realize that you will be taking these hormones for the rest of your life. For the sake of your long term health and well-being, you must chose the safest hormones and delivery system available. The SottoPelle® method is just such a method. Our natural bioidentical pellet approach is simple, straightforward and based on delivering the proper amount of hormone slowly into the blood stream around the clock.

Very importantly, the pellet hormone delivery method transports hormone directly into the blood stream, bypassing the liver, making it a safer alternative than pills. When taking pills, a larger dose must be prescribed in order for it to be of any use. The liver can break down a large portion of it before it can reach general circulation. Pills can also seriously affect clotting factors, lipoproteins and inflammatory factors.

Another commonly used method, injection, relies on side-effect laden synthetic hormones. Long term use is impossible. As treatment proceeds, increasing resistance to the synthetic hormones builds. This resistance results in more frequent injections and further resistance.

Precision Dosing
SottoPelle® tailors your hormone therapy according to your unique needs. We understand how to administer cross-sex hormones. Our goal is to provide hormonal balance, something other methods or even other pellet therapies cannot deliver. Our accurate analysis and dosing eliminate the guesswork, trial and error, as well as standardized dosing.

Meticulous Pellet Insertion
Dr. Tutera developed a precision pellet insertion technique. In his experience, the length of time the implants are effective directly relates to the quality of the pellet combined with the proper implant technique. Other insertion methods often lead to pellet extrusion or further problems related to improper placement.

Call SottoPelle® Today for a Consultation
If you are a transgender male or transgender female looking for safe, effective hormone treatments, call SottoPelle® today. Discover what our remarkably simple, hassle-free method can do for you.